PV+ Cells Enhance Temporal Population Codes but not Stimulus-Related Timing in Auditory Cortex.

ABSTRACT: Spatio-temporal cortical activity patterns relative to both peripheral input and local network activity carry information about stimulus identity and context. GABAergic interneurons are reported to regulate spiking at millisecond precision in response to sensory stimulation and during gamma oscillations; their role in regulating spike timing during induced network bursts is unclear. We investigated this issue in murine auditory thalamo-cortical (TC) brain slices, in which TC afferents induced network bursts similar to previous reports in vivo. Spike timing relative to TC afferent stimulation during bursts was poor in pyramidal cells and SOM+ interneurons. It was more precise in PV+ interneurons, consistent with their reported contribution to spiking precision in pyramidal cells. Optogeneti

SUBMITTER: Krause BM 

PROVIDER: S-EPMC6319178 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature