Metabolic risk factors and the incidence and progression of radiographic hand osteoarthritis: a population-based cohort study.

ABSTRACT:

Objective

To determine whether selected metabolic factors are associated with greater amounts of radiographic hand osteoarthritis (OA) incidence and progression.

Methods

The study identified 706 adults, aged 50-69 years, with hand pain and hand radiographs at baseline, from two population-based cohorts. Metabolic factors (body mass index, hypertension, dyslipidaemia, and diabetes) were ascertained at baseline by direct measurement and medical records. Analyses were undertaken following multiple imputation of missing data, and in complete cases (sensitivity analyses). Multivariable regression models estimated associations between metabolic factors and two measures of radiographic change at 7 years for all participants, individuals free of baseline radiographic OA, and in base

SUBMITTER: Marshall M 

PROVIDER: S-EPMC6319183 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature