Genomic loss of HLA alleles may affect the clinical outcome in low-risk myelodysplastic syndrome patients.

ABSTRACT: The Revised International Prognostic Score and some somatic mutations in myelodysplastic syndrome (MDS) are independently associated with transformation to acute myeloid leukemia (AML). Immunity has also been implicated in the pathogenesis of MDS, although the underlying mechanism remains unclear. We performed a SNP array on chromosome 6 in CD34⁺ purified blasts from 19 patients diagnosed with advanced MDS and 8 patients with other myeloid malignancies to evaluate the presence of loss of heterozygosity (LOH) in HLA and its impact on disease progression. Three patients had acquired copy-neutral LOH (CN-LOH) on 6p arms, which may disrupt antigen presentation and act as a mechanism for immune system evasion. Interestingly, these patients had previously been classified at low risk o

SUBMITTER: Montes P 

PROVIDER: S-EPMC6319343 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature