Soluble CD163 correlates with lipid metabolic adaptations in type 1 diabetes patients during ketoacidosis.

ABSTRACT:

Introduction

Diabetic ketoacidosis (DKA) is associated with inflammation and increased lipolysis. The macrophage activation marker, soluble CD163 (sCD163), is associated with obesity, non-alcoholic fatty liver disease and type 2 diabetes. We aimed to investigate whether sCD163 correlates with key elements of lipolysis in type 1 diabetes patients during mild DKA.

Materials and methods

We investigated nine patients with type 1 diabetes twice during: (i) euglycemic control conditions and a bolus of saline; and (ii) hyperglycemic ketotic conditions induced by lipopolysaccharide administration combined with insulin deprivation. Blood samples, indirect calorimetry, palmitate tracer and adipose tissue biopsies were used to investigate lipid metabolism.

Results

We observed a

SUBMITTER: Svart M 

PROVIDER: S-EPMC6319477 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature