Elevated histone H3 acetylation is associated with genes involved in T lymphocyte activation and glutamate decarboxylase antibody production in patients with type 1 diabetes.

ABSTRACT:

Aims/introduction

Genetic and epigenetic mechanisms have been implicated in the pathogenesis of type 1 diabetes, and histone acetylation is an epigenetic modification pattern that activates gene transcription. However, the genome-wide histone H3 acetylation in new-onset type 1 diabetes patients has not been well described. Accordingly, we aimed to unveil the genome-wide promoter acetylation profile in CD4⁺ T lymphocytes from type 1 diabetes patients, especially for those who are glutamate decarboxylase antibody-positive.

Materials and methods

A total of 12 patients with new-onset type 1 diabetes who were glutamate decarboxylase antibody-positive were enrolled, and 12 healthy individuals were recruited as controls. The global histone H3 acetylation level of CD4

SUBMITTER: Wang Y 

PROVIDER: S-EPMC6319479 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature