Do people living with HIV experience greater age advancement than their HIV-negative counterparts?

ABSTRACT:

Objectives

Despite successful antiretroviral therapy, people living with HIV (PLWH) may show signs of premature/accentuated aging. We compared established biomarkers of aging in PLWH, appropriately chosen HIV-negative individuals, and blood donors, and explored factors associated with biological age advancement.

Design

Cross-sectional analysis of 134 PLWH on suppressive antiretroviral therapy, 79 lifestyle-comparable HIV-negative controls aged 45 years or older from the Co-morBidity in Relation to AIDS (COBRA) cohort, and 35 age-matched blood donors.

Methods

Biological age was estimated using a validated algorithm based on 10 biomarkers. Associations between 'age advancement' (biological minus chronological age) and HIV status/parameters, lifestyle, cytomegalovirus (C

SUBMITTER: De Francesco D 

PROVIDER: S-EPMC6319574 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature