Exploring the transcriptome of resident spinal microglia after collagen antibody-induced arthritis.

ABSTRACT: Recent studies have suggested a sexually dimorphic role of spinal glial cells in the maintenance of mechanical hypersensitivity in rodent models of chronic pain. We have used the collagen antibody-induced arthritis (CAIA) mouse model to examine differences between males and females in the context of spinal regulation of arthritis-induced pain. We have focused on the late phase of this model when joint inflammation has resolved, but mechanical hypersensitivity persists. Although the intensity of substance P, calcitonin gene-related peptide, and galanin immunoreactivity in the spinal cord was not different from controls, the intensity of microglia (Iba-1) and astrocyte (glial fibrillary acidic protein) markers was elevated in both males and females. Intrathecal administration of the glial in

SUBMITTER: Fernandez-Zafra T 

PROVIDER: S-EPMC6319583 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature