Decreased placental and muscular expression of the fibroblast growth factor 19 in gestational diabetes mellitus.

ABSTRACT:

Aims/introduction

Fibroblast growth factor (FGF)19 has been shown to improve glycemic homeostasis and lipid metabolism in animal models. In humans, decreased FGF19 level has been described in diabetes. The present study aimed to investigate the expression of FGF19 in gestational diabetes mellitus (GDM) patients.

Materials and methods

Samples for measurement were obtained from 20 women with GDM and 25 healthy controls. The messenger ribonucleic acid (mRNA) and protein expression levels of FGF19, FGF21 and co-receptor β-klotho (KLB) in the placenta, rectus muscle and subcutaneous fat tissues were quantified by real-time quantitative polymerase chain reaction, western blot and immunohistochemistry, respectively.

Results

Women with GDM had significantly lower mRNA and pro

SUBMITTER: Wang D 

PROVIDER: S-EPMC6319613 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature