Oncogenic BRAF^V600E Governs Regulatory T-cell Recruitment during Melanoma Tumorigenesis.

ABSTRACT: Regulatory T cells (Treg) are critical mediators of immunosuppression in established tumors, although little is known about their role in restraining immunosurveillance during tumorigenesis. Here, we employ an inducible autochthonous model of melanoma to investigate the earliest Treg and CD8 effector T-cell responses during oncogene-driven tumorigenesis. Induction of oncogenic BRAF^V600E and loss of Pten in melanocytes led to localized accumulation of FoxP3⁺ Tregs, but not CD8 T cells, within 1 week of detectable increases in melanocyte differentiation antigen expression. Melanoma tumorigenesis elicited early expansion of shared tumor/self-antigen-specific, thymically derived Tregs in draining lymph nodes, and induced their subsequent recruitment to sites of tumorigene

SUBMITTER: Shabaneh TB 

PROVIDER: S-EPMC6319620 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature