High prevalence of nonalcoholic steatohepatitis and abnormal liver stiffness in a young and obese Mexican population.

ABSTRACT:

Objective

To identify nonalcoholic steatohepatitis (NASH) and liver stiffness in Mexican subjects with different body mass index (BMI).

Methods

A cross-sectional study was conducted in 505 adults. Risk for NASH was defined as the presence of one or more of the following biochemical and metabolic parameters (BMPs): fasting glucose ≥100 mg/dl, triglycerides (TG) ≥150 mg/dl, homeostatic model assessment of insulin resistance (HOMA-IR) ≥2.5, aspartate aminotransferase (AST) >54 IU/L and alanine aminotransferase (ALT) >42 IU/L. Body mass index measurement and nutritional assessment were performed by standard procedures. Liver fibrosis stage was determined by liver stiffness measurement using transitional elastography (TE) or by liver biopsy (LB).

Results

Risk for NASH was

SUBMITTER: Sepulveda-Villegas M 

PROVIDER: S-EPMC6319733 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature