Dynamical anchoring of distant arrhythmia sources by fibrotic regions via restructuring of the activation pattern.

ABSTRACT: Rotors are functional reentry sources identified in clinically relevant cardiac arrhythmias, such as ventricular and atrial fibrillation. Ablation targeting rotor sites has resulted in arrhythmia termination. Recent clinical, experimental and modelling studies demonstrate that rotors are often anchored around fibrotic scars or regions with increased fibrosis. However, the mechanisms leading to abundance of rotors at these locations are not clear. The current study explores the hypothesis whether fibrotic scars just serve as anchoring sites for the rotors or whether there are other active processes which drive the rotors to these fibrotic regions. Rotors were induced at different distances from fibrotic scars of various sizes and degree of fibrosis. Simulations were performed in a 2D model

SUBMITTER: Vandersickel N 

PROVIDER: S-EPMC6319787 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature