Prediction of novel target genes and pathways involved in tall cell variant papillary thyroid carcinoma.

ABSTRACT:

Background

Tall cell variant papillary thyroid carcinoma (TCPTC) is reportedly associated with aggressive clinicopathological parameters and poor outcomes; however, the molecular mechanisms underlying TCPTC remain poorly understood.

Methods

The gene mutation types and mRNA expression profiles of patients with TCPTC were obtained from The Cancer Genome Atlas (TCGA) database. Differentially expressed genes (DEGs) were identified. Pathways in the interaction network and the diagnostic approaches of candidate markers for TCPTC were investigated.

Results

BRAF mutation was particularly prevalent in TCPTC with a mutation frequency of 78%. TCPTC was associated with a patient age >45 years, tumor multifocality, extrathyroidal extension, a higher T stage, advanced AJCC TNM stag

SUBMITTER: Xia F 

PROVIDER: S-EPMC6319788 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature