Effect of adjuvant hormone therapy in patients with prostate cancer: A meta-analysis of randomized controlled trials.

ABSTRACT:

Objectives

To summarize the evidence regarding the treatment effect of adjuvant hormone therapy (AHT) in patients with prostate cancer (PCa). AHT following radiotherapy, chemotherapy, or surgery is widely used in patients with PCa. However, the treatment effect is inconsistent in individual trials.

Methods

The electronic databases including PubMed, EmBase, and Cochrane Library were searched to identify randomized controlled trials (RCTs) in September 2016. RCTs that evaluated the effects of AHT in patients with PCa were included. Hazard ratio (HR) and relative risks (RR) were used to measure the treatment effects of AHT using a random effects model. The analyses were further stratified by factors that could affect the treatment efficacy.

Results

A total of 14,594 pote

SUBMITTER: Liu F 

PROVIDER: S-EPMC6319968 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature