Genome-wide maps of distal gene regulatory enhancers active in the human placenta.

ABSTRACT: Placental dysfunction is implicated in many pregnancy complications, including preeclampsia and preterm birth (PTB). While both these syndromes are influenced by environmental risk factors, they also have a substantial genetic component that is not well understood. Precisely controlled gene expression during development is crucial to proper placental function and often mediated through gene regulatory enhancers. However, we lack accurate maps of placental enhancer activity due to the challenges of assaying the placenta and the difficulty of comprehensively identifying enhancers. To address the gap in our knowledge of gene regulatory elements in the placenta, we used a two-step machine learning pipeline to synthesize existing functional genomics studies, transcription factor (TF) binding pa

SUBMITTER: Zhang J 

PROVIDER: S-EPMC6320013 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature