Effects of HIV-1 TAT protein and methamphetamine exposure on visual discrimination and executive function in mice.

ABSTRACT: Mild neurocognitive impairments are common in people with human immunodeficiency virus (HIV) infection. HIV-encoded proteins, such as trans-activator of transcription (TAT), contribute to neuropathology and cognitive function in medicated subjects. The combination of TAT and comorbid methamphetamine use may further impair neurocognitive function in HIV-positive individuals by affecting dopaminergic systems in the brain. The current study examined the effects of TAT protein expression and methamphetamine exposure on cognitive function and dopamine systems in mice. Transgenic mice with inducible brain expression of the TAT protein were exposed to a binge methamphetamine regimen. TAT expression was induced via a doxycycline-containing diet during the final stage of the regimen and maintained

SUBMITTER: Kesby JP 

PROVIDER: S-EPMC6320247 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature