Disruption of TET2 promotes the therapeutic efficacy of CD19-targeted T cells.

ABSTRACT: Cancer immunotherapy based on genetically redirecting T cells has been used successfully to treat B cell malignancies^1-3. In this strategy, the T cell genome is modified by integration of viral vectors or transposons encoding chimaeric antigen receptors (CARs) that direct tumour cell killing. However, this approach is often limited by the extent of expansion and persistence of CAR T cells^4,5. Here we report mechanistic insights from studies of a patient with chronic lymphocytic leukaemia treated with CAR T cells targeting the CD19 protein. Following infusion of CAR T cells, anti-tumour activity was evident in the peripheral blood, lymph nodes and bone marrow; this activity was accompanied by complete remission. Unexpectedly, at the peak of the response, 94% of CAR T c

SUBMITTER: Fraietta JA 

PROVIDER: S-EPMC6320248 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature