Gene Expression Profiling Reveals Aberrant T-cell Marker Expression on Tumor Cells of Waldenstrom's Macroglobulinemia.

ABSTRACT:

Purpose

That the malignant clone of Waldenström's macroglobulinemia (WM) demonstrates significant intraclonal heterogeneity with respect to plasmacytoid differentiation indicates the mechanistic complexity of tumorigenesis and progression. Identification of WM genes by comparing different stages of B cells may provide novel druggable targets.

Experimental design

The gene expression signatures of CD19⁺ B cells (BC) and CD138⁺ plasma cells (PC) from 19 patients with WM were compared with those of BCs from peripheral blood and tonsil and to those of PCs from the marrow of healthy (N-PC) and multiple myeloma donors (MM-PC), as well as tonsil (T-PC). Flow cytometry and immunofluorescence were used to examine T-cell marker expression on WM tumor cells.

Res

SUBMITTER: Hao M 

PROVIDER: S-EPMC6320275 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature