Early-adolescent male C57BL/6J and DBA/2J mice display reduced sensitivity to acute nicotine administration.

ABSTRACT:

Background

The initial response to nicotine is an important predictor of subsequent use. Multiple factors may alter this response including genetics and age of first use. Here we investigated the influence of age, genetics, and their interaction on nicotine sensitivity. We then examined whether these factors influence the relationship between initial behavioral responses and voluntary nicotine consumption in adulthood.

Methods

We measured initial nicotine responses, including nicotine-induced locomotor depression and hypothermia following an acute intraperitoneal injection (0, 0.5, or 1 mg/kg), during early-adolescence, middle-adolescence, late-adolescence, or adulthood. Thirty-five days after the initial testing, mice were assessed for voluntary oral nicotine consumption.

SUBMITTER: Miller CN 

PROVIDER: S-EPMC6320290 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature