Genetic variation in biotransformation enzymes, air pollution exposures, and risk of spina bifida.

ABSTRACT: Spina bifida is a birth defect characterized by incomplete closure of the embryonic neural tube. Genetic factors as well as environmental factors have been observed to influence risks for spina bifida. Few studies have investigated possible gene-environment interactions that could contribute to spina bifida risk. The aim of this study is to examine the interaction between gene variants in biotransformation enzyme pathways and ambient air pollution exposures and risk of spina bifida. We evaluated the role of air pollution exposure during pregnancy and gene variants of biotransformation enzymes from bloodspots and buccal cells in a California population-based case-control (86 cases of spina bifida and 208 non-malformed controls) study. We considered race/ethnicity and folic acid vitamin use

SUBMITTER: Padula AM 

PROVIDER: S-EPMC6320343 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature