Abcc6 deficiency in mice leads to altered ABC transporter gene expression in metabolic active tissues.

ABSTRACT:

Background

ATP-binding cassette (ABC) transporters are involved in a huge range of physiological processes. Mutations in the ABCC6 gene cause pseudoxanthoma elasticum, a metabolic disease with progressive soft tissue calcification.

Methods

The aim of the present study was to analyze gene expression levels of selected ABC transporters associated with cholesterol homeostasis in metabolic active tissues, such as the liver, kidney and white adipose tissue (WAT) of Abcc6^-/- mice from an early and late disease stage (six-month-old and 12-month-old mice).

Results

The strongest regulation of ABC transporter genes was observed in the liver tissue of six-month-old Abcc6^-/- mice. Here, we found a significant increase of mRNA expression levels of phospholipi

SUBMITTER: Ibold B 

PROVIDER: S-EPMC6320597 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature