Impact of early events and lifestyle on the gut microbiota and metabolic phenotypes in young school-age children.

ABSTRACT:

Background

The gut microbiota evolves from birth and is in early life influenced by events such as birth mode, type of infant feeding, and maternal and infant antibiotics use. However, we still have a gap in our understanding of gut microbiota development in older children, and to what extent early events and pre-school lifestyle modulate the composition of the gut microbiota, and how this impinges on whole body metabolic regulation in school-age children.

Results

Taking advantage of the KOALA Birth Cohort Study, a long-term prospective birth cohort in the Netherlands with extensive collection of high-quality host metadata, we applied shotgun metagenomics sequencing and systematically investigated the gut microbiota of children at 6-9 years of age. We demonstrated an overall

SUBMITTER: Zhong H 

PROVIDER: S-EPMC6320620 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature