Identification of a Siglec-F+ granulocyte-macrophage progenitor.

ABSTRACT: In recent years multi-parameter flow cytometry has enabled identification of cells at major stages in myeloid development; from pluripotent hematopoietic stem cells, through populations with increasingly limited developmental potential (common myeloid progenitors and granulocyte-macrophage progenitors), to terminally differentiated mature cells. Myeloid progenitors are heterogeneous, and the surface markers that define transition states from progenitors to mature cells are poorly characterized. Siglec-F is a surface glycoprotein frequently used in combination with IL-5 receptor alpha (IL5Rα) for the identification of murine eosinophils. Here, we describe a CD11b⁺ Siglec-F+ IL5Rα- myeloid population in the bone marrow of C57BL/6 mice. The CD11b⁺ Siglec-F+ IL5Rα- cells

SUBMITTER: Bolden JE 

PROVIDER: S-EPMC6320667 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature