Network correlation analysis revealed potential new mechanisms for neural tube defects beyond folic acid.

ABSTRACT:

Background

Neural tube defects (NTDs) are clinically significant congenital malformations which are known to be folic acid (FA) responsive, such that supplementation significantly reduces the prevalence of NTDs. Nonetheless, some individuals fail to respond to FA supplementation; hence NTDs remain a significant public health concern. The mechanisms that underlie the beneficial effects of FA supplementation remain poorly understood. Mouse models have been used extensively to study the mechanisms driving neural tube closure (NTC).

Methods

Microarray data of GSE51285 was downloaded from the NCBI GEO database, which contains the RNA expression profiles of livers from five NTD mouse mutants (heterozygous females) and their corresponding wildtype (WT) controls. Those five NTD muta

SUBMITTER: Gao X 

PROVIDER: S-EPMC6320695 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature