The Biological Significance and Regulatory Mechanism of c-Myc Binding Protein 1 (MBP-1).

ABSTRACT: Alternatively translated from the ENO gene and expressed in an array of vertebrate and plant tissues, c-Myc binding protein 1 (MBP-1) participates in the regulation of growth in organisms, their development and their environmental responses. As a transcriptional repressor of multiple proto-oncogenes, vertebrate MBP-1 interacts with other cellular factors to attenuate the proliferation and metastasis of lung, breast, esophageal, gastric, bone, prostrate, colorectal, and cervical cancer cells. Due to its tumor-suppressive property, MBP-1 and its downstream targets have been investigated as potential prognostic markers and therapeutic targets for various cancers. In plants, MBP-1 plays an integral role in regulating growth and development, fertility and abiotic stress responses. A bett

SUBMITTER: Liu Z 

PROVIDER: S-EPMC6320933 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature