Choline-Amino Acid Ionic Liquids as Green Functional Excipients to Enhance Drug Solubility.

ABSTRACT: The development of effective forms to incorporate poorly soluble drugs into delivery systems remains a problem. Thus, it is important to find alternatives such as finding excipients that increase drug solubility. Ionic liquids (ILs), particularly choline-based ILs, have been studied as solubility enhancers in drug delivery systems. Nonetheless, to acknowledge this property as a functionality, it needs to be proven at non-toxic concentrations. Hence, herein two choline-amino acid ILs were studied as functional excipients by evaluating their influence on the solubility of the poorly water-soluble ferulic acid and rutin, while considering their safety. The solubility of the drugs was always higher in the presence of the ILs than in water. Ionic liquids did not affect the radical scavenging ac

SUBMITTER: Caparica R 

PROVIDER: S-EPMC6321021 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature