Interaction of Arylidenechromanone/Flavanone Derivatives with Biological Macromolecules Studied as Human Serum Albumin Binding, Cytotoxic Effect, Biocompatibility Towards Red Blood Cells.

ABSTRACT: The aim of this study was to determine the cytotoxic effect of 3-arylidenechromanone (1) and 3arylideneflavanone (2) on HL-60 and NALM-6 cell lines (two human leukemia cell lines) and a WM-115 melanoma cell line. Both compounds exhibited high cytotoxic activity with higher cytotoxicity exerted by compound 2, for which IC₅₀ values below 10 µM were found for each cell line. For compound 1, the IC₅₀ values were higher than 10 µM for HL-60 and WM-115 cell lines, but IC₅₀ < 10 µM was found for the NALM-6 cell line. Both compounds, at the concentrations close to IC₅₀ (concentration range: 5⁻24 µM/L for compound 1 and 6⁻10 µM/L for compound 2), are not toxic towards red blood cells. The synthesized compounds were characterized using spectroscopic method

SUBMITTER: Adamus-Grabicka AA 

PROVIDER: S-EPMC6321038 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature