Antioxidant Properties and the Formation of Iron Coordination Complexes of 8-Hydroxyquinoline.

ABSTRACT: The alkaloid 8-hydroxyquinoline (8HQ) is well-known for various biological activities, including antioxidant effects and especially for the formation of coordination complexes with various transition metals, such as iron, amongst others. Therefore, 8HQ was extensively explored as a promising antineurodegenerative agent. However, other authors noted pro-oxidant effects of 8HQ. Here, we explore the pro- and antioxidant properties of 8HQ, especially in context of coordination complexes with iron (II) and iron (III). Nano-electrospray-mass spectrometry, differential pulse voltammetry, deoxyribose degradation, iron (II) autoxidation, and brine shrimp mortality assays were used. 8HQ formed a complex mixture of coordination complexes with iron (II) and iron (III). Furthermore, 8HQ showed antioxid

SUBMITTER: Chobot V 

PROVIDER: S-EPMC6321042 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature