YAP Activation Drives Liver Regeneration after Cholestatic Damage Induced by Rbpj Deletion.

ABSTRACT: Liver cholestasis is a chronic liver disease and a major health problem worldwide. Cholestasis is characterised by a decrease in bile flow due to impaired secretion by hepatocytes or by obstruction of bile flow through intra- or extrahepatic bile ducts. Thereby cholestasis can induce ductal proliferation, hepatocyte injury and liver fibrosis. Notch signalling promotes the formation and maturation of bile duct structures. Here we investigated the liver regeneration process in the context of cholestasis induced by disruption of the Notch signalling pathway. Liver-specific deletion of recombination signal binding protein for immunoglobulin kappa j region (Rbpj), which represents a key regulator of Notch signalling, induces severe cholestasis through impaired intra-hepatic bile duct (IH

SUBMITTER: Tharehalli U 

PROVIDER: S-EPMC6321044 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature