Prediction of Signal Peptides in Proteins from Malaria Parasites.

ABSTRACT: Signal peptides are N-terminal presequences responsible for targeting proteins to the endomembrane system, and subsequent subcellular or extracellular compartments, and consequently condition their proper function. The significance of signal peptides stimulates development of new computational methods for their detection. These methods employ learning systems trained on datasets comprising signal peptides from different types of proteins and taxonomic groups. As a result, the accuracy of predictions are high in the case of signal peptides that are well-represented in databases, but might be low in other, atypical cases. Such atypical signal peptides are present in proteins found in apicomplexan parasites, causative agents of malaria and toxoplasmosis. Apicomplexan proteins have a unique am

SUBMITTER: Burdukiewicz M 

PROVIDER: S-EPMC6321056 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature