Development of Parvifloron D-loaded Smart Nanoparticles to Target Pancreatic Cancer.

ABSTRACT: Pancreatic cancer is the eighth leading cause of cancer death worldwide. For this reason, the development of more effective therapies is a major concern for the scientific community. Accordingly, plants belonging to Plectranthus genus and their isolated compounds, such as Parvifloron D, were found to have cytotoxic and antiproliferative activities. However, Parvifloron D is a very low water-soluble compound. Thus, nanotechnology can be a promising delivery system to enhance drug solubility and targeted delivery. The extraction of Parvifloron D from P. ecklonii was optimized through an acetone ultrasound-assisted method and isolated by Flash-Dry Column Chromatography. Then, its antiproliferative effect was selectivity evaluated against different tumor cell lines (IC

SUBMITTER: Santos-Rebelo A 

PROVIDER: S-EPMC6321128 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature