Lymphatic Vascular Structures: A New Aspect in Proliferative Diabetic Retinopathy.

ABSTRACT: Diabetic retinopathy (DR) is the most common diabetic microvascular complication and major cause of blindness in working-age adults. According to the level of microvascular degeneration and ischemic damage, DR is classified into non-proliferative DR (NPDR), and end-stage, proliferative DR (PDR). Despite advances in the disease etiology and pathogenesis, molecular understanding of end-stage PDR, characterized by ischemia- and inflammation-associated neovascularization and fibrosis, remains incomplete due to the limited availability of ideal clinical samples and experimental research models. Since a great portion of patients do not benefit from current treatments, improved therapies are essential. DR is known to be a complex and multifactorial disease featuring the interplay of microvascular

SUBMITTER: Gucciardo E 

PROVIDER: S-EPMC6321212 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature