Childhood-Onset Schizophrenia: Insights from Induced Pluripotent Stem Cells.

ABSTRACT: Childhood-onset schizophrenia (COS) is a rare psychiatric disorder characterized by earlier onset, more severe course, and poorer outcome relative to adult-onset schizophrenia (AOS). Even though, clinical, neuroimaging, and genetic studies support that COS is continuous to AOS. Early neurodevelopmental deviations in COS are thought to be significantly mediated through poorly understood genetic risk factors that may also predispose to long-term outcome. In this review, we discuss findings from induced pluripotent stem cells (iPSCs) that allow the generation of disease-relevant cell types from early brain development. Because iPSCs capture each donor's genotype, case/control studies can uncover molecular and cellular underpinnings of COS. Indeed, recent studies identified alterations in neur

SUBMITTER: Hoffmann A 

PROVIDER: S-EPMC6321410 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature