Facile Preparation of Gold-Decorated Fe₃O₄ Nanoparticles for CT and MR Dual-Modal Imaging.

ABSTRACT: The development of a multifunctional nanoprobe capable of non-invasive multimodal imaging is crucial for precise tumour diagnosis. Herein, we report a facile polymer-assisted method to produce Au-Fe₃O₄ nanocomposites (NCPs) for the dual-modal magnetic resonance (MR) and X-ray computed tomography (CT) imaging of tumours. In this approach, amino-functionalized Au nanospheres were first obtained by surface modification of the bifunctional polymer SH-PEG-NH₂. Hydrophilic and carboxyl-functionalized Fe₃O₄ nanoparticles were produced by phase transfer of reverse micelle oxidation in our previous work. The Au nanoparticles were conjugated with hydrophilic Fe₃O₄ nanoparticles through an amide reaction. The obtained Au-Fe₃O₄ nanocomposites display a high r₂ relativity (157.92 mM-1 s-1) and a Hounsf

SUBMITTER: Cai J 

PROVIDER: S-EPMC6321430 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature