Expression, Localization, and Activity of the Aryl Hydrocarbon Receptor in the Human Placenta.

ABSTRACT: The human placenta is an organ between the blood of the mother and the fetus, which is essential for fetal development. It also plays a role as a selective barrier against environmental pollutants that may bypass epithelial barriers and reach the placenta, with implications for the outcome of pregnancy. The aryl hydrocarbon receptor (AhR) is one of the most important environmental-sensor transcription factors and mediates the metabolism of a wide variety of xenobiotics. Nevertheless, the identification of dietary and endogenous ligands of AhR suggest that it may also fulfil physiological functions with which pollutants may interfere. Placental AhR expression and activity is largely unknown. We established the cartography of AhR expression at transcript and protein levels, its cellular dist

SUBMITTER: Wakx A 

PROVIDER: S-EPMC6321474 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature