Polyamidoamine Nanoparticles for the Oral Administration of Antimalarial Drugs.

ABSTRACT: Current strategies for the mass administration of antimalarial drugs demand oral formulations to target the asexual Plasmodium stages in the peripheral bloodstream, whereas recommendations for future interventions stress the importance of also targeting the transmission stages of the parasite as it passes between humans and mosquitoes. Orally administered polyamidoamine (PAA) nanoparticles conjugated to chloroquine reached the blood circulation and cured Plasmodium yoelii-infected mice, slightly improving the activity of the free drug and inducing in the animals immunity against malaria. Liquid chromatography with tandem mass spectrometry analysis of affinity chromatography-purified PAA ligands suggested a high adhesiveness of PAAs to Plasmodium falciparum proteins, which might be the mech

SUBMITTER: Marti Coma-Cros E 

PROVIDER: S-EPMC6321545 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature