Targeted Theranostic Nanoparticles for Brain Tumor Treatment.

ABSTRACT: The poor prognosis and rapid recurrence of glioblastoma (GB) are associated to its fast-growing process and invasive nature, which make difficult the complete removal of the cancer infiltrated tissues. Additionally, GB heterogeneity within and between patients demands a patient-focused method of treatment. Thus, the implementation of nanotechnology is an attractive approach considering all anatomic issues of GB, since it will potentially improve brain drug distribution, due to the interaction between the blood⁻brain barrier and nanoparticles (NPs). In recent years, theranostic techniques have also been proposed and regarded as promising. NPs are advantageous for this application, due to their respective size, easy surface modification and versatility to integrate multiple functional compon

SUBMITTER: Mendes M 

PROVIDER: S-EPMC6321593 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature