Epigenome-wide association study of serum cotinine in current smokers reveals novel genetically driven loci.

ABSTRACT:

Background

DNA methylation alteration extensively associates with smoking and is a plausible link between smoking and adverse health. We examined the association between epigenome-wide DNA methylation and serum cotinine levels as a proxy of nicotine exposure and smoking quantity, assessed the role of SNPs in these associations, and evaluated molecular mediation by methylation in a sample of biochemically verified current smokers (N = 310).

Results

DNA methylation at 50 CpG sites was associated (FDR < 0.05) with cotinine levels, 17 of which are novel associations. As cotinine levels are influenced not only by nicotine intake but also by CYP2A6-mediated nicotine metabolism rate, we performed secondary analyses adjusting for genetic risk score of nicotine metabolism rate and id

SUBMITTER: Gupta R 

PROVIDER: S-EPMC6321663 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature