Subclinical tuberculosis among adults with HIV: clinical features and outcomes in a South African cohort.

ABSTRACT:

Background

Subclinical tuberculosis is an asymptomatic disease phase with important relevance to persons living with HIV. We describe the prevalence, clinical characteristics, and risk of mortality for HIV-infected adults with subclinical tuberculosis.

Methods

Untreated adults with HIV presenting for outpatient care in Durban, South Africa were screened for tuberculosis-related symptoms and had sputum tested by acid-fast bacilli smear and tuberculosis culture. Active tuberculosis and subclinical tuberculosis were defined as having any tuberculosis symptom or no tuberculosis symptoms with culture-positive sputum. We evaluated the association between tuberculosis disease category and 12-month survival using Cox regression, adjusting for age, sex, and CD4 count.

Results

SUBMITTER: Bajema KL 

PROVIDER: S-EPMC6321698 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature