Steroidal glycoalkaloids from Solanum nigrum target cytoskeletal proteins: an in silico analysis.

ABSTRACT:

Background

Solanum nigrum (black nightshade; S. nigrum), a member of family Solanaceae, has been endowed with a heterogeneous array of secondary metabolites of which the steroidal glycoalkaloids (SGAs) and steroidal saponins (SS) have vast potential to serve as anticancer agents. Since there has been much controversy regarding safety of use of glycoalkaloids as anticancer agents, this area has remained more or less unexplored. Cytoskeletal proteins like actin play an important role in maintaining cell shape, synchronizing cell division, cell motility, etc. and along with their accessory proteins may also serve as important therapeutic targets for potential anticancer candidates. In the present study, glycoalkaloids and saponins from S. nigrum were screened for

SUBMITTER: Ahmad R 

PROVIDER: S-EPMC6321755 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature