Phthalates exposure and uterine fibroid burden among women undergoing surgical treatment for fibroids: a preliminary study.

ABSTRACT:

Objectives

To examine the association between phthalate exposure and two measures of uterine fibroid burden: diameter of largest fibroid and uterine volume.

Design

Pilot, cross-sectional study.

Setting

Academic medical center.

Patient(s)

Fifty-seven premenopausal women undergoing either hysterectomy or myomectomy for fibroids.

Intervention(s)

None.

Main outcome measure(s)

The diameter of the largest fibroid and uterine dimensions were abstracted from medical records. Spot urine samples were analyzed for 14 phthalate biomarkers using mass spectrometry. We estimated associations between fibroid outcomes and individual phthalate metabolites, sum of di(2-ethylhexyl) phthalate metabolites (∑DEHP), and a weighted sum of anti-androgenic phthalate metabol

SUBMITTER: Zota AR 

PROVIDER: S-EPMC6321778 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature