Chronic in vivo angiotensin II administration differentially modulates the slow delayed rectifier channels in atrial and ventricular myocytes.

ABSTRACT:

Background

In the heart, slow delayed rectifier channels provide outward currents (I_Ks) for action potential (AP) repolarization in a region- and context-dependent manner. In diseased hearts, chronic elevation of angiotensin II (Ang II) may remodel I_Ks in a region-dependent manner, contributing to atrial and ventricular arrhythmias of different mechanisms.

Objective

The purpose of this study was to study whether/how chronic in vivo Ang II administration remodels I_Ks in atrial and ventricular myocytes.

Methods

We used the guinea pig (GP) model whose myocytes express robust I_Ks. GPs were implanted with minipumps containing Ang II or vehicle. Treatment continued for 4-6 weeks. We used patch clamp, immunofluorescence/confocal mi

SUBMITTER: Zankov DP 

PROVIDER: S-EPMC6321789 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature