Mettl3 Deficiency Sustains Long-Chain Fatty Acid Absorption through Suppressing Traf6-Dependent Inflammation Response.

ABSTRACT: A better understanding of the molecular mechanism of intestinal fatty acid absorption could lead to novel approaches to treatment and prevention of fatty acid-related metabolic diseases. Although it is confirmed that absorption of long-chain fatty acids (LCFAs) decreases during the pathological processes, the genetic basis and molecular mechanisms remain largely unknown. N ⁶-methyladenosine (m⁶A) is the most prevalent internal modification on eukaryotic mRNA. Recently, m⁶A has been found to play important roles in inflammation and antiviral responses. In this study, we show that deficiency of Mettl3, the core methyltransferase of m⁶A, exerts antimalabsorption of LCFA activity in vitro through inhibiting the inflammation response mediated b

SUBMITTER: Zong X 

PROVIDER: S-EPMC6321842 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature