Norovirus Transmission Dynamics in a Pediatric Hospital Using Full Genome Sequences.

ABSTRACT:

Background

Norovirus is a leading cause of worldwide and nosocomial gastroenteritis. The study aim was to assess the utility of molecular epidemiology using full genome sequences compared to routine infection prevention and control (IPC) investigations.

Methods

Norovirus genomes were generated from new episodes of norovirus at a pediatric tertiary referral hospital over a 19-month period (n = 182). Phylogeny identified clusters of related sequences that were verified using epidemiological and clinical data.

Results

Twenty-four clusters of related norovirus sequences ("sequence clusters") were observed, including 8 previously identified by IPC investigations ("IPC outbreaks"). Seventeen sequence clusters (involving 77/182 patients) were corroborated by epidemiological

SUBMITTER: Brown JR 

PROVIDER: S-EPMC6321856 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature