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Wear data for trials machining brass, titanium grade 2 and Hastelloy in order to characterize wear of micro-tools.

ABSTRACT: This data article presents data on machining trials that were carried out using 0.5 mm micro-end-mills with different coatings to characterize their wear. The data take the following forms: Tabulated wear measurements, cutting force measurements and graphs of wear against sliding distance. Three materials were machined: titanium grade 2, Hastelloy and Brass (CuZn37). Wear is measured on the flank, rake face and outside edge of the tools. Two coatings were used for each material, with wear data plotted for each material. For further information on experimental methods please refer to "Protocol for Tool Wear Measurement in Micro-milling" (Alhadeff et al., 2018).

SUBMITTER: Alhadeff LL

PROVIDER: S-EPMC6321860 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature

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Wear data for trials machining brass, titanium grade 2 and Hastelloy in order to characterize wear of micro-tools.

Alhadeff L L LL Marshall M B MB Slatter T T

Data in brief 20181218

This data article presents data on machining trials that were carried out using 0.5 mm micro-end-mills with different coatings to characterize their wear. The data take the following forms: Tabulated wear measurements, cutting force measurements and graphs of wear against sliding distance. Three materials were machined: titanium grade 2, Hastelloy and Brass (CuZn37). Wear is measured on the flank, rake face and outside edge of the tools. Two coatings were used for each material, with wear data p ...[more]

PMID: 30627611

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Project description:Wear particle‑induced osteolysis is a serious complication that occurs in individuals with titanium (Ti)‑based implants following long‑term usage due to loosening of the implants. The control of excessive osteoclast differentiation and inflammation is essential for protecting against wear particle‑induced osteolysis. The present study evaluated the effect of britanin, a pseudoguaianolide sesquiterpene isolated from Inula japonica, on osteoclastogenesis in vitro and Ti particle‑induced osteolysis in vivo. The effect of britanin was examined in the osteoclastogenesis of mouse bone marrow‑derived macrophages (BMMs) using TRAP staining, RT‑PCR, western blotting and immunocytochemistry. The protective effect of britanin was examined in a mouse calvarial osteolysis model and evaluated using micro‑CT and histomorphometry. Britanin inhibited osteoclast differentiation and F‑actin ring formation in the presence of macrophage colony‑stimulating factor and receptor activator of nuclear factor kB ligand in BMMs. The expression of osteoclast‑specific marker genes, including tartrate‑resistant acid phosphatase, cathepsin K, dendritic cell‑specific transmembrane protein, matrix metallopeptidase 9 and nuclear factor of activated T‑cells cytoplasmic 1, in the BMMs was significantly reduced by britanin. In addition, britanin reduced the expression of B lymphocyte‑induced maturation protein‑1, which is a transcriptional repressor of negative osteoclastogenesis regulators, including interferon regulatory factor‑8 and B‑cell lymphoma 6. Conversely, britanin increased the expression levels of anti‑oxidative stress genes, namely nuclear factor erythroid‑2‑related factor 2, NAD(P)H quinone oxidoreductase 1 and heme oxygenase 1 in the BMMs. Furthermore, the administration of britanin significantly reduced osteolysis in a Ti particle‑induced calvarial osteolysis mouse model. Based on these findings, it is suggested that britanin may be a potential therapeutic agent for wear particle‑induced osteolysis and osteoclast‑associated disease.

Dataset Information

Wear data for trials machining brass, titanium grade 2 and Hastelloy in order to characterize wear of micro-tools.

Publications

Wear data for trials machining brass, titanium grade 2 and Hastelloy in order to characterize wear of micro-tools.

Similar Datasets

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