P73 Is Required for pIgR Expression in the Respiratory Epithelium

ABSTRACT: Rationale: The polymeric immunoglobulin receptor (pIgR) is required for transport of secretory immunoglobulin A across the airway epithelium. Secretory immunoglobulin A helps maintain homeostasis in the airways by preventing bacterial invasion and has been implicated in the pathogenesis of chronic obstructive pulmonary disease. Objectives: We investigated whether loss of p73, a transcription factor expressed primarily by multiciliated cells (MCCs), reduces pIgR expression in mice. Methods: pIgR expression in p73 null mice (CMV.Cre/Flox-p73) was determined by immunostaining of lung sections and tracheal epithelial cells (TECs) differentiated at the air–liquid interface. pIgR expression in TECs from mice with respiratory epithelium–specific or MCC-specific loss of p73 (SPC.Cre/Flox-p73 and F

SUBMITTER: Richmond B 

PROVIDER: S-EPMC6322007 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature