Fibromyalgia: Genetics and epigenetics insights may provide the basis for the development of diagnostic biomarkers.

ABSTRACT: Fibromyalgia is a disease characterized by chronic widespread pain with additional symptoms, such as joint stiffness, fatigue, sleep disturbance, cognitive dysfunction, and depression. Currently, fibromyalgia diagnosis is based exclusively on a comprehensive clinical assessment, according to 2016 ACR criteria, but validated biological biomarkers associated with fibromyalgia have not yet been identified. Genome-wide association studies investigated genes potentially involved in fibromyalgia pathogenesis highlighting that genetic factors are possibly responsible for up to 50% of the disease susceptibility. Potential candidate genes found associated to fibromyalgia are SLC64A4, TRPV2, MYT1L, and NRXN3. Furthermore, a gene-environmental interaction has been proposed as triggering mechanism, th

SUBMITTER: D'Agnelli S 

PROVIDER: S-EPMC6322092 | biostudies-literature | 2019 Jan-Dec

REPOSITORIES: biostudies-literature