Recent advances in Kaposi sarcoma herpesvirus-associated multicentric Castleman disease.

ABSTRACT:

Purpose of review

The discovery of Kaposi sarcoma herpesvirus (KSHV) led to recognition of KSHV-associated multicentric Castleman disease (MCD) as a distinct lymphoproliferative disorder. The pathogenesis of KSHV-MCD is attributed to proliferation of KSHV-infected B cells, production of KSHV-encoded viral interleukin 6 by these cells, and dysregulation of human interleukin 6 and interleukin 10. This article reviews advances in the field of disease pathogenesis and targeted therapies.

Recent findings

Our understanding of the pathogenesis of KSHV-MCD has increased in recent years and improved therapies have been developed. Recent studies demonstrate that the anti-CD20 monoclonal antibody, rituximab, as well as virus-activated cytotoxic therapy using high-dose zidovudine and va

SUBMITTER: Uldrick TS 

PROVIDER: S-EPMC6322210 | biostudies-literature | 2012 Sep

REPOSITORIES: biostudies-literature