Investigation of a Cluster of Sphingomonas koreensis Infections.

ABSTRACT:

Background

Plumbing systems are an infrequent but known reservoir for opportunistic microbial pathogens that can infect hospitalized patients. In 2016, a cluster of clinical sphingomonas infections prompted an investigation.

Methods

We performed whole-genome DNA sequencing on clinical isolates of multidrug-resistant Sphingomonas koreensis identified from 2006 through 2016 at the National Institutes of Health (NIH) Clinical Center. We cultured S. koreensis from the sinks in patient rooms and performed both whole-genome and shotgun metagenomic sequencing to identify a reservoir within the infrastructure of the hospital. These isolates were compared with clinical and environmental S. koreensis isolates obtained from other institutions.

Results

The investigation showed th

SUBMITTER: Johnson RC 

PROVIDER: S-EPMC6322212 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature