Evidence for long noncoding RNA GAS5 up-regulationin patients with Klinefelter syndrome.

ABSTRACT:

Background

Klinefelter syndrome (KS) is characterized by the presence of at least one supernumerary X chromosome. KS typical symptoms include tall stature, gynecomastia, hypogonadism and azoospermia. KS patients show a higher risk of developing metabolic and cardiovascular diseases, inflammatory and autoimmune disorders, osteoporosis and cancer. Long non-coding RNA (lncRNA) growth arrest-specific 5 (GAS5) has been shown to be involved in several biologic processes, including inflammatory and autoimmune diseases, vascular endothelial cells apoptosis and atherosclerosis, as well as cellular growth and proliferation, cellular development and cell-to-cell signaling and interaction. The lncRNA GAS5 expression profile in KS patients has never been evaluated so far.

Methods

To acco

SUBMITTER: Salemi M 

PROVIDER: S-EPMC6322229 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature