Loss of intestinal sympathetic innervation elicits an innate immune driven colitis.

ABSTRACT:

Background

Both the parasympathetic and sympathetic nervous system exert control over innate immune responses. In inflammatory bowel disease, sympathetic innervation in intestinal mucosa is reduced. Our aim was to investigate the role of sympathetic innervation to the intestine on regulation of the innate immune responses.

Methods

In lipopolysaccharide (LPS)-stimulated macrophages, we evaluated the effect of adrenergic receptor activation on cytokine production and metabolic profile. In vivo, the effect of sympathetic denervation on mucosal innate immune responses using 6-hydroxydopamine (6-OHDA), or using surgical transection of the superior mesenteric nerve (sympathectomy) was tested in Rag1^-/- mice that lack T- and B-lymphocytes.

Results

In murine macrop

SUBMITTER: Willemze RA 

PROVIDER: S-EPMC6322236 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature